Like every other substance, CBD can produce some undesirable side effects, or interact with the active ingredients of several other drugs. Common side effects of CBD can include nausea, irritability, dry mouth, and lightheadedness. The presence of these side effects varies from person to person depending on the dosage and mode of ingestion. These side effects also present themselves during the first few weeks of usage and are more pronounced after the dosage is significantly increased during regular use. To prevent these side effects, it is important to carefully decide on the best delivery method and slowly increase the dosage until you get your desired results.
There are more serious side effects that are less common and usually occur when CBD is used with other drugs. This is because CBD binds with certain enzymes in the body and disrupt the way other drugs and processed and metabolized in the body. Specifically, CBD binds with the CYP450 enzyme that helps to break down and eliminate drugs, leaving the drugs unprocessed in the liver and the bloodstream which leads to higher levels of the drugs being retained in the system rather than eliminated.
Research has also proven CBD to be a potent inhibitor of CYP3A4 and CYP2D6, enzymes responsible for the processing of benzodiazepines, antihistamines, and antidepressants. It is important to consult with your doctor about taking CBD with other medications, as the interaction can lead to you having a dangerously high dose or even overdosing on the other medication. Since CBD also affects the concentration of other drugs in the bloodstream and liver, it is necessary to use a lower dose of CBD if you have any problems with your liver.
CBD is known to lower blood pressure but can be dangerous for people already dealing with low blood pressure. Trace levels of CBD can also be passed on from mother to child while breastfeeding, and while there isn’t sufficient evidence on how CBD affects a developing baby, it is necessary to avoid using CBD during pregnancy or while breastfeeding.